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Prebiotic Supplementation During Pregnancy Modifies the Gut Microbiota and Increases Metabolites in Amniotic Fluid, Driving a Tolerogenic Environment In UteroThe gut microbiota is influenced by environmental factors such as food. Maternal diet during pregnancy modifies the gut microbiota composition and function, leading to the production of specific compounds that are transferred to the fetus and enhance the ontogeny and maturation of the immune system. Prebiotics are fermented by gut bacteria, leading to the release of short-chain fatty acids that can specifically interact with the immune system, inducing a switch toward tolerogenic populations and therefore conferring health benefits.
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Effects of diurnal exercise timing on appetite, energy intake and body composition: A parallel randomized trialTo determine the effect of diurnal exercise timing on appetite, energy intake and body composition in individuals with overweight or obesity.
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Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespanChanges in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high-fat diet modulates mitochondrial translation and affects lifespan in mutant mice with error-prone or hyper-accurate mitochondrial ribosomes. Intriguingly, although both mutations are metabolically beneficial in reducing body weight, decreasing circulating insulin and increasing glucose tolerance during a high-fat diet, they manifest divergent (either deleterious or beneficial) outcomes in a tissue-specific manner.
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Modelling the effects of beverage substitution during adolescence on later obesity outcomes in early adulthood: Results from the raine studySugar-sweetened beverage intake during adolescence was associated with higher body mass index, waist circumference, and being overweight in early adulthood
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Maternal fish oil supplementation in pregnancy: a 12 year follow-up of a randomised controlled trial.We aimed to investigate the long-term effects (12 years) of fish oil supplementation in pregnancy on neurodevelopment, including cognition, language and fine...
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Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control studyIn this case-control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the...
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Food sources of saturated fat and the association with mortality: A meta-analysisThere is an ongoing need for improvement in assessment tools and methods that investigate food sources of saturated fat and mortality to inform dietary...
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Nutritional Influences on Epigenetic Programming. Asthma, Allergy, and ObesityReliance on increasing use of dietary supplementation and fortification (eg, with folate) to compensate for increased consumption of processed foods is also...
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Spective associations between sugar-sweetened beverage intakes and cardiometabolic risk factors in adolescentsIncreased SSB intake may be an important predictor of cardiometabolic risk in young people, independent of weight status.
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Both Dietary Protein and Fat Increase Postprandial Glucose Excursions in Children With Type 1 DiabetesOur objective was to determine the separate and combined effects of high-protein (HP) and high-fat (HF) meals, with the same carbohydrate content, on...