Search
Showing results for "early lung health"
Our team aims to optimise lung health early in life to ensure the best possible health outcomes later in life.
Research
The potential of antisense oligonucleotide therapies for inherited childhood lung diseasesAntisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.
Research
The ventilatory response to hypoxia is blunted in some preterm infants during the second year of lifePreterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.
Research
Respiratory function in healthy Emirati children using forced oscillationsForced oscillation technique measurements were feasible in Emirati school-children. New forced oscillation technique reference equation in Emirati children were derived.
Research
Influence of secular trends and sample size on reference equations for lung function testsThe aim of our study was to determine the contribution of secular trends and sample size to lung function reference equations, and establish the number...
Research
The all-age spirometry reference ranges reflect contemporary Australasian spirometryAdvances in statistical modelling have allowed the creation of smoothly changing spirometry reference ranges that apply across a wide age range and better...
Research
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung functionPulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease.
Research
PELICAN: Prematurity’s Effects on the Lungs in Children and Adults NetworkThe PELICAN (Prematurity’s Effects on the Lungs in Children and Adults Network) Clinical Research Collaboration was launched by the European Respiratory Society (ERS) in 2020
Research
Collecting exhaled breath condensate from non-ventilated preterm-born infants: a modified methodExhaled breath condensate (EBC) collection is a non-invasive, safe method for measurement of biomarkers in patients with lung disease. Other methods of obtaining samples from the lungs, such as bronchoalveolar lavage, are invasive and require anaesthesia/sedation in neonates and infants. EBC is particularly appealing for assessing biomarkers in preterm-born infants, a population at risk of ongoing lung disease.
Research
Early respiratory viral infections in infants with cystic fibrosisEarly viral infections were associated with greater neutrophilic inflammation and bacterial pathogens