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News & Events
Meet the Researcher: Dr Gina TrappDr Gina Trapp is the Head of Food and Nutrition – driven to leading her team in becoming a hub of child and adolescent nutrition research globally.
Research
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
In 2020, we celebrated our 30th birthday with those who matter most — the kids whose lives we’ve changed through the research we do.
Research
Global Scales for Early Development: Piloting the Family Check Up ProgramEvery year, over 80,000 Western Australian children will have a diagnosed mental health disorder.
Research
Standardization of epidemiological surveillance of group A Streptococcal cellulitisCellulitis is an acute bacterial infection of the dermis and subcutaneous tissue usually found complicating a wound, ulcer, or dermatosis. This article provides guidelines for the surveillance of cellulitis.
News & Events
Meet the Finalists: Illuminate PitchFest 2024Illuminate PitchFest is back! We are excited to introduce you to 10 trailblazing researchers who will be taking to the stage this February to pitch their bold and bright ideas.
News & Events
Repeated stress in pregnancy linked to children's behaviourResearch has found a link between the number of stressful events experienced during pregnancy and increased risk of behavioural problems in children.
Research
PLAYCE PAWS: The health and developmental benefits of companion animals for young childrenPet ownership is associated with a number of physical, mental and emotional health benefits. Our current Pets and Health study (PLAYCE PAWS) investigates the health and developmental benefits of companion animals for young children.
Research
Feasibility of home-based urine collection in children under 5 years in the ORIGINS birth cohort study: mixed method protocol and sample completion resultsUrine is an attractive biospecimen for nutritional status and population health surveys. It is an excellent non-invasive alternative to blood for appropriate biomarkers in young children and is suitable for home-based collection, enabling representative collections across a population. However, the bulk of literature in this population is restricted to collection in primary care settings.
Research
From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progressGlioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients alike. Despite advancements in brain cancer research driven by a technological revolution, translating our understanding of glioblastoma pathogenesis into improved clinical outcomes remains a critical unmet need.