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Introducing the ORIGINS project: a community-based interventional birth cohortNon-communicable diseases (NCDs) pose the greatest threat to human health globally. The dramatic rise in early onset NCDs - such as childhood obesity, the allergy epidemic and an increasing burden of mental ill health in children and youth - reflect the profound early impact of modern environments on developing systems.
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Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine ResponseEpidemiological studies have demonstrated that survivors of acute burn trauma are at long-term increased risk of developing a range of morbidities. The mechanisms underlying this increased risk remain unknown. This study aimed to determine whether burn injury leads to sustained immune dysfunction that may underpin long-term morbidity. Plasma and peripheral blood mononuclear cells were collected from 36 pediatric burn survivors >3 years after a non-severe burn injury (<10% total body surface area) and from age/sex-matched non-injured controls.
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Children's neighbourhood physical environment and early development: an individual child level linked data studyThe neighbourhood physical environment has a weak but significant association with early childhood development
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Stillbirth risk prediction using machine learning for a large cohort of births from Western Australia, 1980–2015Almost half of stillbirths could be potentially identified antenatally based on a combination of factors
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Analytical bias in the measurement of plasma 25-hydroxyvitamin D concentrations in infantsTo our knowledge, this is the first study to show that the reported 25(OH)D concentration may be influenced by both age and assay type
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Acute Rheumatic Fever and Rheumatic Heart Disease, 1st EditionAcute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective
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Topical antiseptics for chronic suppurative otitis mediaThe effectiveness and safety profile of antiseptics in the treatment of chronic suppurative otitis media is uncertain
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A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord bloodNeonatal dendritic cells generated form CD34+ cord blood progenitors have a higher inflammatory potential when exposed to viral than bacterial related stimuli
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Early life exposure to coal mine fire smoke emissions and altered lung function in young childrenInfant exposure to coal mine fire emissions could be associated with long-term impairment of lung reactance
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Cochrane corner: interventions to prevent hearing loss caused by noise at workThe aim of this Cochrane Review was to find out if hearing loss caused by noise at work is being prevented by current interventions