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A study to prolong breastfeeding duration: Design and rationale of the Parent Infant Feeding Initiative (PIFI) randomised controlled trial.This study aimed to measure the effectiveness of three interventions designed to increase the duration of breastfeeding among new parents in urban areas.
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Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapyTime-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tumor RNA sequencing data in the context of treatment with ICB in murine models of AB1 mesothelioma and Renca renal cell cancer.
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Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation early developmentThe predominant occurrence of extragonadal teratomas/teratocarcinomas in human neonates suggests that pluripotent cells are tumour-forming even during...
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Parents on the Concept of Physical Literacy: What Do They Know, What Do They Do, and What Do They Want?Physical literacy development in early childhood, viewed by many as the foundation for lifelong physical activity engagement, is significantly influenced by parents. Our aim was to explore parents' understanding of physical literacy and gain insight into their perspectives on physical literacy promotion.
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Encouraging the positive use of technology through community engagementDescribe a seven stage community engagement process to develop and disseminate community uptake strategies which encouraged cyber safety
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Severe outcomes of malaria in children under time-varying exposureIn malaria epidemiology, interpolation frameworks based on available observations are critical for policy decisions and interpreting disease burden. Updating our understanding of the empirical evidence across different populations, settings, and timeframes is crucial to improving inference for supporting public health.
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IL-17A-producing γδ T cells suppress early control of parasite growth by monocytes in the liverThis study examines the role of IL-17 in mice infected with L. donovani and discovered an unexpected negative, regulatory role for this cytokine in the...
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Prematurity-associated lung disease: is it asthma?Shannon Elizabeth Simpson Smith BMedSci (hons), PhD PhD, MSc, BSc Head, Strong Beginnings Research, Co-head Foundations of Lung Disease Program
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Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms
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Enablers and barriers to primary health care access for Indigenous adolescents: a systematic review and meta-aggregation of studies across Australia, Canada, New Zealand, and USAIndigenous adolescents access primary health care services at lower rates, despite their greater health needs and experience of disadvantage. This systematic review identifies the enablers and barriers to primary health care access for Indigenous adolescents to inform service and policy improvements.
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Key findings from the second Australian Child and Adolescent Survey of Mental Health and WellbeingThe prevalence of mental disorders in children and adolescents in Australia, and the severity and impact of those mental disorders
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The use of honey in the perioperative care of tonsillectomy patients-A narrative reviewTonsillectomy is one of the most common surgical procedures in childhood. While generally safe, it often is associated with a difficult early recovery phase with poor oral intake, dehydration, difficult or painful swallowing, postoperative bleeding, infection and/or otalgia.
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An observational study of febrile seizures: The importance of viral infection and immunizationDetermine the frequency of detection of specific viral pathogens in children with febrile seizures
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Assessing emotion beliefs with the Polish version of the Emotion Beliefs Questionnaire (EBQ): psychometric properties, norms, and links with emotional reactivity and psychopathologyOriginally developed in English, the Emotion Beliefs Questionnaire (EBQ) is a self-report measure of beliefs about the controllability and usefulness of negative and positive emotions. In this study, we introduce the Polish version and examine its psychometric properties and links with emotional outcomes. Our sample was 914 Polish adults aged 18–70 from the general population.
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The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axisIn cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.
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Azithromycin reduces bronchial wall thickening in infants with cystic fibrosisCOMBAT-CF showed that children aged 0-3 years treated with azithromycin did clinically better than placebo but there was no effect on CT-scores. We reanalysed CTs using an automatic bronchus-artery (BA) analysis.
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Boosting the influenza vaccine schedule in children with cancer: a prospective open-label studyCurrent immunization guidelines recommend one dose of influenza vaccine for children aged ≥9 years and two doses for younger or vaccine-naïve children. However, children receiving chemotherapy have an attenuated immune response. We performed a prospective open-label study in children undergoing treatment for cancer at Perth Children's Hospital, Western Australia, to examine the safety and efficacy of a boosted influenza schedule.