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The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes.
In Western countries, Asian children have higher food allergy risk than Caucasian children. The early-life environmental exposures for this discrepancy are unclear. We aimed to compare prevalence of food allergy and associated risk factors between Asian children in Singapore and Australia.
Showed for the first time that the presence of an egg-derived allergen in breast milk is associated with a reduced risk of egg allergy in children at 2.5 years of age
Australian infants who received whole-cell pertussis vaccines were less likely to be diagnosed with food allergy in childhood
This study highlights an unpredicted potential risk factor for the development of food allergy, that is, D pteronyssinus allergens in breast milk
Infant feeding practices in Australia have changed over the past decade; a large majority of infants are now fed peanut before 12 months of age
We conclude that genuine serious allergic reaction to propofol is rare and is not reliably predicted by a history of food allergy
We systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation
In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention
To assess the efficacy and adverse events of epicutaneous immunotherapy with a peanut patch among peanut-allergic children