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Acute rheumatic fever (ARF) is an abnormal immune reaction following Streptococcus pyogenes (Strep A) infection of the throat, and likely the skin. Primary prevention is the prompt and appropriate antibiotic treatment of Strep A infection, and it can reduce the risk of developing ARF and subsequent rheumatic heart disease.

The diagnosis of acute rheumatic fever relies on a combination of clinical evaluation and laboratory studies. Diagnosis is usually made using the Jones criteria, which have recently been updated in 2015.

The rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys

This study sought to determine relationships, by gender, between childhood behaviour problems and adolescent risky sexual behaviours and substance use.

This study was designed to determine the sensitivity and reproducibility of recovering anti-streptolysin O titres (ASOT) from dried blood spot (DBS) samples

Indigenous Australians are much more likely to die from Rheumatic Heart Disease than other Australians.

This review outlines a clinical development strategy detailing the phases of development required for registration of a candidate Group A streptococci vaccin

Echocardiographic screening for rheumatic heart disease is cost-effective in our context

The prognosis of young Indigenous Australians diagnosed with severe RHD is bleak; interventions must focus on earlier detection and treatment

We aimed to review RHD burden in Western Pacific Region outside Oceania to identify countries with high RHD burden