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Assessment of Cannabidiol and Delta9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and EpendymomaChildren with medulloblastoma and ependymoma are treated with a multidisciplinary approach that incorporates surgery, radiotherapy, and chemotherapy; however, overall survival rates for patients with high-risk disease remain unsatisfactory. Data indicate that plant-derived cannabinoids are effective against adult glioblastoma; however, preclinical evidence supporting their use in pediatric brain cancers is lacking. Here we investigated the potential role for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in medulloblastoma and ependymoma. Dose-dependent cytotoxicity of medulloblastoma and ependymoma cells was induced by THC and CBD in vitro, and a synergistic reduction in viability was observed when both drugs were combined.
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The high prevalence and impact of rheumatic heart disease in pregnancy in First Nations populations in a high-income setting: a prospective cohort studyRheumatic heart disease in pregnancy persists in First Nations people in Australia and New Zealand and is associated with major cardiac and perinatal morbidity
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A broad autism phenotype expressed in facial morphologyThese data provide the first evidence for a broad autism phenotype expressed in a physical characteristic
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Online self-compassion training to improve the wellbeing of youth with chronic medical conditions: Protocol for a randomised control trialThe Self-Compassion Online program could provide a scalable solution for improving psychological outcomes and quality of life among youth with chronic illness
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Priorities for improved management of acute rheumatic fever and rheumatic heart diseaseThe results suggest that timely injection and patient education are priorities for managing ARF and RHD, particularly focusing on child-to-adult transition care.
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Qualitative study of psychosocial factors impacting on Aboriginal women's management of chronic diseaseThe caring roles and responsibilities Aboriginal women have in their community impact on their health
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Harmonised collection of data in youth mental health: Towards large datasetsThe use of this core set of data will facilitate the pooling of psychopathological and neurobiological data into large datasets
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Immune-mediated ECM depletion improves tumour perfusion and payload deliveryWe have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds
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Child and adolescent psychiatry training in Australia and New ZealandThis article highlights the requirements of the training programs for Child and Adolescent Psychiatry in Australia and New Zealand
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Tumor necrosis factor α induces α1B-adrenergic receptor expression in keratinocytesOur results suggest that inflammatory cytokines released during injury stimulate α1-AR expression in keratinocytes