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Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factorsEpigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.
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Fetal alcohol spectrum disorder and the criminal justice systemFetal Alcohol Spectrum Disorder (FASD) is a condition caused by prenatal exposure to alcohol and characterised by severe neurodevelopmental impairment which have lifelong implications. Impairments in executive function, memory, cognition, language and attention are common, and can lead to early and repeat engagement with the criminal justice system.
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Childhood vaccination and allergy: A systematic review and meta-analysisAs the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy.
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Pre-exposure prophylaxis for HIV prevention during pregnancy and lactation: forget not the women and childrenThe framework for appropriately identifying and managing at-risk pregnant and lactating women requiring PrEP is poorly defined
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Evolving Trends of Gastrostomy Insertion Within a Pediatric PopulationNew gastrostomy insertion among children who require long-term enteral feeding support increased over the study period
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Assessment of on-time vaccination coverage in population subgroups: A record linkage cohort studyOn-time coverage of the 2-4-6 month schedule is only 50-60% across specific population subgroups representing a significant avoidable public health risk
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Functional differences in airway dendritic cells determine susceptibility to IgE-sensitizationRespiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma.
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DNA methylation-based classification of central nervous system tumoursHere we present an approach for the DNA methylation-based classification of central nervous system tumors across all groups and demonstrate its application.
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Multidrug-resistant tuberculosis in Australia, 1998-2012Multidrug-resistant tuberculosis is uncommon in Australia
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Use of health services in the last year of life and cause of death in people with intellectual disability: a retrospective matched cohort studyPeople with intellectual disability were more likely to experience potentially preventable conditions at the end of their lives