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Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditionsOne explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...
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Virus infection and allergy in the development of asthma: What is the connection?Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy.
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Quantification of Serum Ovalbumin-specific Immunoglobulin E Titre via in vivo Passive Cutaneous Anaphylaxis AssayWe describe herein a highly reproducible in vivo passive cutaneous anaphylaxis assay using Sprague Dawley rats for the quantification of ovalbumin-specific IgE
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A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources.Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular...
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The complement system in systemic lupus erythematosus: An updateThe complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). This review highlights the many roles of complement for
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Attenuation of maternal inflammatory responses during pregnancy to promote normal immune and behavioral outcomes in the offspringThis study will identify how the immune system contributes to neurodevelopmental outcomes and will investigate the use of an agent from traditional medicines.
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Long-term derangement of antigen presenting cell populations in the respiratory tract following Influenza A infectionThis project investigates how different populations of cells within the respiratory tract immune system are altered during a viral infection.
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A pathogenic role for the integrin CD103 in experimental allergic airways diseaseRole for CD103 in the pathogenesis of experimental allergic airways disease in BALB/c mice through local control of CD4+ T cell and DC subset recruitment
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Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesisHematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell...
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Defective respiratory tract immune surveillance in asthma : A primary causal factor in disease onset and progressionThe relative importance of respiratory viral infections vs inhalant allergy in asthma pathogenesis is the subject of ongoing debate.