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A microRNA-based dynamic risk score for type 1 diabetesIdentifying individuals at high risk of type 1 diabetes (T1D) is crucial as disease-delaying medications are available. Here we report a microRNA (miRNA)-based dynamic (responsive to the environment) risk score developed using multicenter, multiethnic and multicountry ('multicontext') cohorts for T1D risk stratification. Discovery (wet and dry lab) analysis identified 50 miRNAs associated with functional β cell loss, which is a hallmark of T1D.
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Fetal alcohol spectrum disorders: Using knowledge, attitudes and practice of justice professionals to support their educational needsThere was widespread agreement of the need for more information and training about FASD to optimise outcomes for people with FASD engaging with justice system
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Out-of-Home Care versus In-home Care for Children Who Have Been Maltreated: A Systematic Review of Health and Wellbeing OutcomesCompared developmental health or wellbeing outcomes for maltreated children placed in out-of-home care with those cared for in their home
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CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangementsIdentified CCI-007 as a novel small molecule that displays rapid toxicity towards a subset of MLL-r, CALM-AF10 and SET-NUP214 leukemia cell lines
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Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infectionIRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections in HBE cells
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School policies on bullying and cyberbullying: perspectives across three Australian statesThe perspectives of professionals involved in bullying and cyberbullying policy construction, across three different Australian states
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Cerebral palsy and perinatal mortality after pregnancy-induced hypertension across the gestational age spectrum: Observations of a reconstructed total population cohortThis reconstructed total population cohort paper investigates the relationship between cerebral palsy & pregnancy induced hypertension.
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ViPAR: A software platform for the Virtual Pooling and Analysis of Research DataViPAR is a secure, flexible and powerful analysis platform built on open source technology that is currently in use by large international consortia
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Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: A systematic review and meta-analysisFindings confirm substantial reductions in heart rate variability across psychiatric disorders, and remained significant even in medication-free individuals
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The relationship between central and peripheral oxytocin concentrations: A systematic review and meta-analysis protocolSystematic review and meta-analysis will synthesize evidence to determine if there is an association between central and peripheral oxytocin concentrations