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Research

An observational study of antibody responses to a primary or subsequent pertussis booster vaccination in Australian healthcare workers

Adult pertussis vaccination is increasingly recommended to control pertussis in the community. However, there is little data on the duration and kinetics of immunity to pertussis boosters in adults. We compared IgG responses to vaccination with a tetanus, low-dose diphtheria, low-dose acellular pertussis (Tdap) booster at 1 week, 1 month and 1 year post-vaccination in whole-cell (wP)-primed Australian paediatric healthcare workers who had received an adult Tdap booster 5-12 years previously, to those who received their first Tdap booster.

News & Events

Cholesterol and blood pressure drugs help teens with diabetes

Researchers from the Children’s Diabetes Centre have had a lead role in a global adolescent Type 1 Diabetes study.

News & Events

Diabetes and the new school year

It is important to make sure your school has an up-to-date diabetes management plan now that school has begun.

Research

An evaluation of GPT models for phenotype concept recognition

Clinical deep phenotyping and phenotype annotation play a critical role in both the diagnosis of patients with rare disorders as well as in building computationally-tractable knowledge in the rare disorders field.

News & Events

Community forum and symposium a big success

The Children’s Diabetes Centre was honoured to have leading international experts Laurel Messer and Professor Mike Riddell as guest speakers at its community forum and research symposium recently.

Research

The effect of TNF treatment uptake on incident hospital admission in Western Australia

Treatment strategies for juvenile idiopathic arthritis (JIA) have shifted significantly over the last 20 years. We examined the effect of the introduction of government-subsidised TNF inhibitor (TNFi) treatment on incident hospitalisation for JIA.

News & Events

Local researchers lead biggest ‘artificial pancreas’ outpatient study

The Children’s Diabetes Centre at The Kids Research Institute Australia is leading the longest and largest at-home trial of a hybrid closed-loop insulin pump system.

News & Events

Donated pump a blessing for Kye

Looking at him now, it’s hard to believe busy one-year-old toddler Kye Gilbert was extremely unwell in Perth Children’s Hospital’s critical care unit with a new diagnosis of type 1 diabetes just a few months ago.

Research

Hypoglycaemia in Diabetes

Iatrogenic hypoglycaemia is one of the main limiting factors in the glycaemic management of diabetes. It causes negative biological, psychological, and social consequences in most people with type 1 diabetes and in many with advanced type 2 diabetes. This chapter explores physiological homeostatic mechanisms that prevent hypoglycaemia through glucose counter-regulation, before discussing specific acquired defects of glucose counter-regulation in diabetes, which provides an insight into risk factors for hypoglycaemia.