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Novel end points for clinical trials in young children with cystic fibrosisCystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality.
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Going back to the future with Guthrie-powered epigenome-wide association studiesEpigenome-wide association studies (EWAS) can be used to investigate links between early life environment, epigenetics and disease...
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Dendritic cells and multiple sclerosis: Disease, tolerance and therapyMultiple sclerosis (MS) is a devastating neurological disease that predominantly affects young adults resulting in severe personal and economic impact.
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Lung function and exhaled nitric oxide in healthy unsedated African infantsPopulation-appropriate lung function reference data are essential to accurately identify respiratory disease and measure response to interventions.
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Effects of adopting the new global lung function initiative 2012 reference equations on the interpretation of spirometryThe aim of this study was to document the likely interpretative effects of changing from commonly used current spirometry reference equations to the GLI2012...
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A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab FamilyWe performed a discovery GWAS in an extended UAE family (N = 178; 66 diabetic; 112 healthy) genotyped on the Illumina Human 660 Quad Beadchip, with...
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Utility of auscultatory screening for detecting rheumatic heart disease in high-risk children in Australia's Northern TerritorySensitivity and positive predictive value of cardiac auscultation compared with echocardiography is poor, regardless of the expertise of the auscultator.
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Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axisWe aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation...
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Associations between aggressive behaviour scores and cardiovascular risk factors in childhoodThe objective of this study was to examine the influence of aggressive behaviour scores on cardiovascular disease (CVD) risk factors throughout childhood.
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Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the AbsenceVitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator.