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Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restrictionThe rat model demonstrates that intrauterine growth restriction leads to a more heterogeneous distribution of airway lumen calibre in adulthood
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Rhinovirus exacerbates house-dust-mite induced lung disease in adult miceIn this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to...
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The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in miceMineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community...
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The influence of moving walls on respiratory aerosol deposition modellingThis work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel...
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Acute diesel exhaust particle exposure increases viral titre and inflammation associated with existing influenzaExposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases.
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Chronic carbon dioxide exposure: an unrecognised health risk of climate change?Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate
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Understanding how viral infection in early life impacts on lung function in adulthoodAlexander David Deborah Larcombe Martino Strickland A DM DH BScEnv (Hons) PhD BSc PhD PhD Head, Respiratory Environmental Health Head, Clinical
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Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse modelTreatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
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In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in miceIn utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...
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Sexual dimorphism in lung function responses to acute influenza A infectionMales are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and...