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News & Events
Exercise summit wrap upThe Children’s Diabetes Centre recently held summits for young people with Type 1 Diabetes to get their input into the development of new exercise guidelines.
Research
Hypoglycaemia in DiabetesIatrogenic hypoglycaemia is one of the main limiting factors in the glycaemic management of diabetes. It causes negative biological, psychological, and social consequences in most people with type 1 diabetes and in many with advanced type 2 diabetes. This chapter explores physiological homeostatic mechanisms that prevent hypoglycaemia through glucose counter-regulation, before discussing specific acquired defects of glucose counter-regulation in diabetes, which provides an insight into risk factors for hypoglycaemia.
News & Events
Donated pump a blessing for KyeLooking at him now, it’s hard to believe busy one-year-old toddler Kye Gilbert was extremely unwell in Perth Children’s Hospital’s critical care unit with a new diagnosis of type 1 diabetes just a few months ago.
Research
Vector fields of risk: A new approach to the geographical representation of childhood asthmaOne of the major challenges in health studies with a spatial dimension is to produce valid and meaningful geographical representations of risk.
News & Events
Oscar Hogan - How my brother living with T1D influenced my careerWe spoke to Oscar and asked him to share his story about the challenges he faces when trying to support his brother, joining the Centre as a student and what T1D research means to him, his brother and his family.
News & Events
Crippa's Footy ClinicDiabetes Research Western Australia (DRWA) are inviting children aged 6-16 living with type 1 and type 2 diabetes to join West Coast Eagles forward Jamie Cripps for a fun-filled footy clinic.
News & Events
Should I send my child to school?With Term 2 commencing this week, many parents are unsure as to whether to send their child with type 1 diabetes back to school. To assist parents with their own decision-making process, it is important to consider the individual risks and benefits for each family.
Research
"i Think i Could Have Used It Better": Experiences of Youth with High HbA1c Commencing Advanced Hybrid Closed-Loop Therapy in a Clinical Trial Setting - A Qualitative ResearchAdvanced hybrid closed-loop (AHCL) therapy improves glycemia. However, it is not known if there is an improvement in overall outcomes with AHCL for youth with type 1 diabetes (T1D) at high risk of diabetes-related complications. The study aimed to capture the experiences of youth with suboptimal glycemic control when commencing AHCL therapy in a clinical trial setting.
Research
Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive CombinationsAntibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemotherapy is widely used in combination with immune checkpoint blockade (ICB). Although a variety of isolated immunostimulatory effects have been reported for several classes of chemotherapeutics, it is unclear which chemotherapeutics provide the most benefit when combined with ICB.