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Research

Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemotherapy is widely used in combination with immune checkpoint blockade (ICB). Although a variety of isolated immunostimulatory effects have been reported for several classes of chemotherapeutics, it is unclear which chemotherapeutics provide the most benefit when combined with ICB.

Research

Vector fields of risk: A new approach to the geographical representation of childhood asthma

One of the major challenges in health studies with a spatial dimension is to produce valid and meaningful geographical representations of risk.

Research

The CoolCot trial: active methods of therapeutic hypothermia for newborns with hypoxic ischaemic encephalopathy during neonatal transport: a study protocol for a randomised controlled trial

Impaired oxygen delivery or blood flow to the brain around the time of birth can cause injury. Hypoxic ischaemic encephalopathy is a leading cause of death and disability in term and near-term infants.

Research

Study protocol for Healthy Conversations @ Playgroup: a multi-site cluster randomized controlled trial of an intervention to promote healthy lifestyle behaviours in young children attending community playgroups

Early childhood is a critical window for preventing obesity and chronic disease. Yet, 1 in 4 Australian children aged 5 years and under are affected by overweight or obesity; and significant proportions of children under 5 years fail to meet guidelines for diet quality, physical activity (PA), screen time, and sleep.

News & Events

Recruitment for AdDIT now complete

Young people diagnosed with Type 1 Diabetes are at risk of complications from their diabetes including kidney, heart, eye and vascular disease.

Research

Changes in thymic regulatory T-cell maturation from birth to puberty: Differences in atopic children

We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young...

Research

Use of Hybrid Closed Loop therapy in hypoglycaemia awareness

This study will tell us if the use of a hybrid closed loop system can improve awareness of hypoglycaemia.

Research

Cyberbullying and the role of the law in Australian schools: Views of senior officials

Opinions of employees from the education and legal systems, regarding their perceptions of the role of the law and cyberbullying in Australian schools

News & Events

Congratulations 2023 Round Two scholarship recipients

The Rio Tinto Children’s Diabetes Centre; a JDRF Global Centre of Excellence (the Centre), announces 2023 Round 2, Honours and PhD scholarships for students dedicated to type 1 diabetes (T1D) research.

News & Events

Sisters strive to succeed

Ashlyn and Kayleigh have much more in common than being siblings – they both excel in their chosen sport and live with type 1 diabetes. We spoke to the sisters about juggling exercise and diabetes.