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Research

Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemotherapy is widely used in combination with immune checkpoint blockade (ICB). Although a variety of isolated immunostimulatory effects have been reported for several classes of chemotherapeutics, it is unclear which chemotherapeutics provide the most benefit when combined with ICB.

Research

Meningococcal serogroup B-specific responses after vaccination with bivalent rLP2086

Assessment of the persistence of bactericidal antibodies up to 4 years after a three-dose schedule of bivalent rLP2086

News & Events

Avid cyclist Theo Grant completes Everesting event

WA teenager Theo Grant has been living with type 1 diabetes since he was two-years-old, but the condition hasn't stopped him from setting big goals

News & Events

School well equipped to deal with diabetes

Meet Nathan, Hayley and Aiden. They all live with Type 1 Diabetes (T1D) and attend the same primary school.

Research

Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data

Given limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical trial in relation to regional and national type 1 diabetes reference populations. 

Research

Antenatal services for Aboriginal women: the relevance of cultural competence

Due to persistent significantly poorer Aboriginal perinatal outcomes, the Women's and Newborns' Health Network, require a comprehensive appraisal...

News & Events

Service availability

Are you tired of being on waitlists to access supports for your family? CliniKids has immediate availability for a number of therapies and programs in clinic (Subiaco and Joondalup) or via telehealth.

Research

Emerging Early Life Environmental Exposures and Lung Development

In this review article we systematically summarize the evidence for an impact on lung development of 1) maternal ingestion of arsenic contaminated drinking...

An adapted novel flow cytometry methodology to delineate types of cell death in airway epithelial cells

An adapted novel flow cytometry methodology to delineate types of cell death in airway epithelial cells Cystic fibrosis (CF) lung disease is

Research

The CoolCot trial: active methods of therapeutic hypothermia for newborns with hypoxic ischaemic encephalopathy during neonatal transport: a study protocol for a randomised controlled trial

Impaired oxygen delivery or blood flow to the brain around the time of birth can cause injury. Hypoxic ischaemic encephalopathy is a leading cause of death and disability in term and near-term infants.