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Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergiesReasons for Th2 skewing in IgE-mediated food allergies remains unclear. Clinical observations suggest impaired T cell activation may drive Th2 responses evidenced by increased atopic manifestations in liver transplant patients on tacrolimus (a calcineurin inhibitor). We aimed to assess differentiation potential, T cell activation and calcium influx of naïve CD4+ T cells in children with IgE-mediated food allergies.
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A newborn's perspective on immune responses to foodIn this review, we will highlight infants' immune responses to food, emphasizing the unique aspects of early-life immunity and the critical role of breast milk as a food dedicated to infants. Infants are susceptible to inflammatory responses rather than immune tolerance at the mucosal and skin barriers, necessitating strategies to promote oral tolerance that consider this susceptibility.
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Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy in inducing desensitisation or tolerance in children with peanut allergy compared with oral immunotherapyPeanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. There is currently no effective long-term treatment. There is a pressing need for definitive treatments that improve the quality of life and prevent fatalities.
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Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: A randomized controlled trialIncreased maternal egg ingestion is associated with increased breastmilk ovalbumin, and markers of immune tolerance in infants
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The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapiesThis article discusses the relationships between gut colonization & inflammatory noncommunicable diseases, in regards to their treatment and prevention.
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Mechanisms of allergic disease - environmental and genetic determinants for the development of allergyEnvironmental exposures including maternal inflammation, diet, nutrient balance, microbial colonization and toxin exposures can directly and indirectly...
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Consensus of stakeholders on precautionary allergen labelling: A report from the Centre for Food and Allergy ResearchPrecautionary allergen labelling is the main tool available to indicate safety levels for food-allergic consumers with regard to potential allergens
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Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infantsThe diagnosis of food allergy (FA) can be challenging because approximately half of food-sensitized patients are asymptomatic.
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Cohort profile of the HealthNuts study: Population prevalence and environmental/genetic predictors of food allergyHealthNuts is a single-centre, multi-wave, population-based longitudinal study designed to assess prevalence, determinants, natural history and allergy...
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Gene polymorphisms, breast-feeding, and development of food sensitization in early childhoodThe effect of breast-feeding on the development of allergic disease is uncertain