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Efficacy of human papillomavirus 16 and 18 vaccine against cervical cancer: Final randomized, double-blind PATRICIA trialWe report final event-driven analysis data on the immunogenicity and efficacy of the human papillomavirus 16 and 18 (HPV-16/18) AS04-adjuvanted vaccine in...
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New genetic loci link adipose and insulin biology to body fat distributionPathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing...
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Early pulmonary inflammation and lung damage in children with cystic fibrosisAirway inflammation and infection are present from early in life, often before children are symptomatic.
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Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeabilityHRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15
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Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forwardReview treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context
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Informing rubella vaccination strategies in East Java, Indonesia through transmission modellingA single dose of rubella vaccine will take longer to reduce the burden of rubella and will be less robust to lower vaccine coverage
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Chronic HIV-1 infection induces B-cell dysfunction that is incompletely resolved by long-term antiretroviral therapyB-cell dysfunction persists in patients with HIV receiving long-term antiretroviral therapy. the causes and consequences of this require further investigation.
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Effectiveness of seasonal trivalent influenza vaccination against hospital-attended acute respiratory infections in pregnant womenInfluenza vaccination during pregnancy was associated with significantly fewer hospital attendances for ARI in pregnant women
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CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangementsIdentified CCI-007 as a novel small molecule that displays rapid toxicity towards a subset of MLL-r, CALM-AF10 and SET-NUP214 leukemia cell lines
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Levels of innate immune factors in preterm and term mothers' breast milk during the 1st month postpartumPreterm breast milk contains significantly higher concentrations of some immune proteins than term breast milk