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Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infectionsThis paper reports on treatment, and preventing infection in close contact, of invasive group A streptococcal (iGAS) using the antibiotic clindamycin and...
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Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the AbsenceVitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator.
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Associations between aggressive behaviour scores and cardiovascular risk factors in childhoodThe objective of this study was to examine the influence of aggressive behaviour scores on cardiovascular disease (CVD) risk factors throughout childhood.
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The mechanism of deep inspiration-induced bronchoprotection: Evidence from a mouse modelIn healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed...
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Analysis of glucose responses to automated insulin suspension with sensor-augmented pump therapyThe advent of sensor-augmented pump therapy with a low-glucose suspend (LGS) function.
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Does enhanced cognitive behaviour therapy for eating disorders improve quality of life?Quality of life (QOL) is the degree of enjoyment and satisfaction experienced in life, and embraces emotional well-being, physical health, economic and...
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Going back to the future with Guthrie-powered epigenome-wide association studiesEpigenome-wide association studies (EWAS) can be used to investigate links between early life environment, epigenetics and disease...
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Psychometric evaluation of clinician- and caregiver-reported clinical severity assessments for individuals with CDKL5 deficiency disorderThe CDKL5 Clinical Severity Assessment is a comprehensive, content-validated measurement tool capturing the diverse challenges of cyclin-dependent kinase-like 5 deficiency disorder, a genetically caused developmental epileptic encephalopathy. The CCSA is divided into clinician-reported and caregiver-reported assessments. The aim of this study was to evaluate the factor structure of these measures through confirmatory factor analysis and evaluate their validity and reliability.
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Ion channel modulator DPI-201-106 significantly enhances antitumor activity of DNA damage response inhibitors in glioblastomaGlioblastoma, a lethal high-grade glioma, has not seen improvements in clinical outcomes in nearly 30 years. Ion channels are increasingly associated with tumorigenesis, and there are hundreds of brain-penetrant drugs that inhibit ion channels, representing an untapped therapeutic resource. The aim of this exploratory drug study was to screen an ion channel drug library against patient-derived glioblastoma cells to identify new treatments for brain cancer.
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BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trialBacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to determine whether BCG vaccination protects adults against COVID-19.