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Lung inflammation and impaired alveolarization precede bronchopulmonary dysplasia (BPD). Glucocorticoids are anti-inflammatory and reduce ventilator requirements in preterm infants. However, high-dose glucocorticoids inhibit alveolarization. The effect of glucocorticoids on lung function and structure in preterm newborns exposed to antenatal inflammation is unknown. We hypothesise that postnatal low-dose dexamethasone reduces ventilator requirements, prevents inflammation and BPD-like lung pathology, following antenatal inflammation.
New research from Perth’s The Kids Research Institute Australia shows that babies born premature continue to have lung problems well into childhood.
A new study to determine if it’s safe for children who were born preterm to attend day care officially commenced this month.
Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.
Limited evidence suggests that airway epithelial structure and function is disrupted in very preterm infants; however, the epithelial morphology and physiology has not been well characterised following discharge from neonatal intensive care. This study aimed to characterise the nasal airway epithelium from 1-year-old survivors of very preterm birth.
Ventilated preterm infant lungs are vulnerable to overdistension and underinflation.
A link between chronic lung disease and low Vitamin D levels is the focus of a new study just started by the Telethon Institute for Child Health Research.
The Kids research has uncovered likely mechanisms for the link between arsenic in drinking water and higher risk of developing chronic lung disease.
Alexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids