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Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivoUVB-induced p53-mediated cell cycle arrest and apoptosis are reduced in the presence of heat stress, leading to increased survival of DNA damaged cells
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Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposityThis paper examined the link between low serum Vitamin D levels and development of non-alcoholic fatty liver disease (NAFLD) in adolescents between 14 and 17...
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Maternal vitamin D status during pregnancy and bone mass in offspring at 20 years of age: A prospective cohort studyThis longitudinal, prospective study investigated the association between maternal vitamin D status and peak bone mass of offspring in 341 mother and...
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Toward homeostasis: Regulatory dendritic cells from the bone marrow of mice with inflammationInflammatory mediators from peripheral tissues may control dendritic cell (DC) development in the bone marrow.
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The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2The anti-inflammatory actions of IL-4 in activated human monocytes may reflect transcriptional regulation of genes involved in TLR signaling pathways.
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Immunobiology & Immunotherapeutic ProgramListed are The Kids Research Institute Australia research teams involved in our Immunity and Inflammation Program. This program sits under the Early Environment research theme.
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Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort studyVitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children with established disease,but its role in disease inception...
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The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1)While it is known that the anti-inflammatory effects of interleukin (IL)-4 require new protein synthesis, the exact mechanisms by which IL-4 suppresses the prod
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Vitamin D deficiency linked to childhood asthmaResearchers at The Kids Research Institute Australia have found children with vitamin D deficiency are more likely to develop asthma.
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Effects of UVR exposure on the gut microbiota of mice and humansBoth human and murine studies report that multiple exposures to sub-erythemal UV radiation can increase the diversity of the gut microbiome