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Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrityIn disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset.
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Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change ModelingClimate change models predict that atmospheric carbon dioxide [CO2] levels will be between 700 and 900 ppm within the next 80yrs. In this study we aimed to assess the respiratory structure and function effects of long-term exposure to 890ppm CO2 from preconception to adulthood using a mouse model.
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Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size?Citation: Donovan GM, Wang KCW, Elliot JG, James AL, Noble PB. Quantifying airway remodelling for research or clinical purposes: How should we
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Intrauterine growth restriction affects diaphragm function in adult female and male miceSex and intrauterine growth restriction independently affect diaphragm contraction in adult mice without changes in structure
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Editorial overview: Endocrine and metabolic adaptations to extreme environments: Living life to the extreme – insights into the limits of life and transitions to diseaseThe need to understand responses to extreme environments has prompted this edition of Current Opinion in Endocrine and Metabolic Research
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The effects of electronic cigarette aerosol exposure on inflammation and lung function in miceThis study shows, for the first time, that exposure to e-cigarette aerosol during adolescence and early adulthood is not harmless to the lungs and can result in significant impairments in lung function.
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Fragranced consumer products: effects on asthmatic AustraliansMost asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects
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Independent and combined effects of airway remodelling and allergy on airway responsivenessThere was a positive relationship between the thickness of the airway smooth muscle layer with airway responsiveness, which was shifted upward in the presence of allergy
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Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthmaFindings provide further proof of concept that pharmacological targeting of airway smooth muscle thickness will be beneficial and may be facilitated by azithromycin
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A cross-sectional survey of environmental health in remote Aboriginal communities in Western AustraliaPoor environmental health is prevalent in remote Aboriginal communities and requires further delineation to inform environmental health policy