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Research

Beyond bone: the emerging role of osteoclasts in immune regulation, leukemia development and following myeloablative therapy

Osteoclasts are important regulators of bone remodeling, with an established role in maintaining skeletal homeostasis. The emergence of osteoimmunology has identified osteoclasts as key players in the immune system. In particular, osteoclasts can initiate bi-directional crosstalk mechanisms with hematopoietic stem cells and various immune cells, such as T cells, B cells and NK cells, to influence hematopoiesis and inflammatory response.

Closing the Gap - Hitting ‘reset’ on how we measure early development in Aboriginal kids

In 2020, the National Closing the Gap partnership made improving early development of Aboriginal and Torres Strait Islander children one of its top priorities. Australia will measure progress in this area using the AEDC.

Research

Gender Diversity

Not all children or teenagers identify with the gender they were assigned at birth. As a result, some may choose to change their name, their clothes or their body. With considerably higher rates of depression, anxiety, self-harm and attempted suicide, the need for specialist mental health services has been recognised.

Research

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors

CD8+ T cells are an important weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cells with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognoses, the tumor microenvironment also contains dysfunctional exhausted T (TEX) cells that exhibit a variety of TRM-like features.

Research

The definition of asthma remission in children: A scoping review by the WAO Paediatric Asthma Committee

Asthma remission has emerged as a potential therapeutic goal. However, definitions of remission have primarily focused on adult populations, with limited consensus on how remission should be defined in children.

Research

Leukaemia

Leukaemia, also spelled leukemia, is a cancer that develops in the bone marrow and results in abnormal white blood cells. It is the most common cancer in children, accounting for almost a third of all childhood & teen cancers.

Research

Pertussis

Pertussis, also known as whooping cough, is a highly contagious respiratory disease.

Reflect and review

Time to reflect After your leadership team has completed an activity it is important to take time to reflect on how it went and things you may have

Cybersafe practices

Cybersafe practices are precautions we can take to make sure our interactions online are safe and positive. Download the "My Online Status" in the

About us

The Health Promotion and Education Research Team at The Kids Research Institute Australia received funding from the auDA Foundation to develop this