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Research

No dose-dependent increase in fracture risk after long-term exposure to high doses of retinol or beta-carotene

This intervention study found no increase in fracture risk among 2,322 adults who took a controlled, high-dose retinol supplement (25,000 IU retinyl...

Research

Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western Australia

Clustering of cases of malignant mesothelioma within families has often been observed, but disentangling genetic and exposure effects has not been done.

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Dietary fructose in relation to blood pressure and serum uric acid in adolescent boys and girls

Evidence that fructose intake may modify blood pressure is generally limited to adult populations.

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Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region

The major burden of disease is in developing and tropical settings where topical antibiotics are impractical and lead to rapid emergence of antimicrobial...

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Autism spectrum disorder in children born preterm: Role of exposure to perinatal inflammation

This review aims to summarise and evaluate the potential mechanisms and evidence for the role of prenatal infection on the central nervous system, and how it...

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A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab Family

We performed a discovery GWAS in an extended UAE family (N = 178; 66 diabetic; 112 healthy) genotyped on the Illumina Human 660 Quad Beadchip, with...

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Effects of adopting the new global lung function initiative 2012 reference equations on the interpretation of spirometry

The aim of this study was to document the likely interpretative effects of changing from commonly used current spirometry reference equations to the GLI2012...

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Novel end points for clinical trials in young children with cystic fibrosis

Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality.

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Genetic and epigenetic susceptibility to early life infection

To date there have been relatively few studies on genetic determinants of susceptibility to neonatal infection and many of these have methodological...

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The Childhood Leukemia International Consortium

The Childhood Leukemia International Consortium (CLIC) was established in 2007 to promote investigations of rarer exposures, gene-environment interactions...