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Research
Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human LifeNeonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform.
Research
Infant feeding and growth trajectory patterns in childhood and body composition in young adulthoodFull breastfeeding for <3 months compared with ≥3 months may be associated with rapid growth in early childhood and body composition in young adulthood
Research
Five-Year Antibody Persistence And Safety Following a Combined Haemophilus Influenzae Neisseria Meningitidis Tetanus Toxoid VaccinesThe purpose of this article is to investigate whether the number and timing of stressors experienced during pregnancy impacted longterm motor development at...
Research
Lot-to-lot consistency of a tetravalent dengue vaccine in healthy adults in Australia: A randomised studyThis trial tested the safety & consistency of the immune responses elicited by three consecutive lots of tetravalent dengue vaccine.
News & Events
New phone triage systemYou may have noticed some changes to the phone triage system for Perth Children’s Hospital’s diabetes clinic recently.
News & Events
New position to help roll out schools programA Clinical Nurse Specialist position within Perth Children’s Hospital’s Diabetes Service has been funded as part of the Federal Government’s new Type 1 Diabetes Management in School program.
News & Events
Welcome to the team Amelia!We’re super excited to welcome Dr Amelia Harray to our research team. Amelia looks forward to strengthening the focus on food research to help children with type 1 diabetes and their families.
Research
Psychomotor Vigilance Testing on Neonatal Transport: A Western Australian ExperienceThis study aimed to assess whether undertaking retrieval was associated with fatigue independent of sleep and circadian disruption. It also aimed to assess the feasibility of routinely measuring the psychomotor vigilance test on neonatal transport. Fatigue is associated with impaired clinician performance and safety.
Research
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art ReviewReducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary atherosclerosis despite no SMuRFs. SMuRFless patients presenting with myocardial infarction have been observed to have an unexpected higher early mortality compared to their counterparts with at least 1 SMuRF.
Research
Relationship Between Social Motivation in Children With Autism Spectrum Disorder and Their ParentsImpairment in social motivation (SM) has been suggested as a key mechanism underlying social communication deficits observed in autism spectrum disorder (ASD). However, the factors accounting for variability in SM remain poorly described and understood. The current study aimed to characterize the relationship between parental and proband SM. Data from 2,759 children with ASD and their parents from the Simons Simplex Collection (SSC) project was included in this study.