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Persistent negative symptoms in individuals at Ultra High Risk for psychosisPersistent negative symptoms can be detected early, allowing for the identification of a subset of Ultra High Risk patients who are likely to have poor outcome
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Tissue-resident memory T cells orchestrate tumour-immune equilibriumOur findings provide insight into the immune cell populations important for maintaining long-term tumour dormancy in peripheral tissues
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Early life innate immune signatures of persistent food allergyEarly life innate immune dysfunction may represent a key immunological driver and predictor of persistent food allergy in childhood
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PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding proteinOur findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
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Cardiometabolic risk factors at 5 years after omega-3 fatty acid supplementation in infancySupplementation with n-3 LCPUFA in infancy revealed a reduction in waist circumference at 5 years
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Cochrane corner: hearing aids for mild to moderate hearing loss in adultsThe evidence supports the widespread provision of hearing aids as the first-line clinical management for those seeking help for hearing difficulties
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Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated SyndromeIgG3 levels and proportions of IgG3 (%IgG) in serum at CIS diagnosis were inversely correlated with the time until conversion to MS
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Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosisHigher IDO and ARG expression in clinically isolated syndrome and multiple sclerosis provides one sustained homeostatic mechanism to control multiple sclerosis-associated inflammation
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Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targetingThis review concentrates on the phosphoethanolamine decoration of lipid A in the pathogenic species of the genus Neisseria
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Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthoodLung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period