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The potential of antisense oligonucleotide therapies for inherited childhood lung diseasesAntisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.
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T-cell responses against rhinovirus species A and C in asthmatic and healthy childrenInfections by RV species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other respiratory disease.
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Attenuated psychophysiological reactivity following single-session group imagery rescripting versus verbal restructuring in social anxiety disorderThe current study highlights the specificity of brief imagery-based interventions in influencing psychophysiological reactivity in social anxiety disorder
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Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysisWe think that variants in genes involved in fructose metabolism and ChREBP-FGF21 pathway interacts with SSB intake to exacerbate associations with SSB intake.
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Cuffed vs. uncuffed tracheal tubes in children: A randomised controlled trial comparing leak, tidal volume and complicationsOur study compared tidal volume and leakage around cuffed and uncuffed tracheal tubes in children who required standardised mechanical ventilation of the lungs.
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Identification of health risk behaviours among adolescent refugees resettling in Western AustraliaWe aim to identify health risk behaviours among adolescent refugees resettling in WA and assess the feasibility of using a standardised questionnaire.
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A Novel Approach to Transforming Smoking Cessation Practice for Pregnant Aboriginal Women and Girls Living in the PilbaraTobacco smoking during pregnancy contributes to a range of adverse perinatal outcomes; but is a potentially modifiable behavior.
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Oral health experiences of individuals with Rett syndrome: A retrospective studySocial advantage may provide some protection for dental health in individuals with Rett syndrome
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Study protocol for the Australian autism biobank: an international resource to advance autism discovery researchThe Australian Autism Biobank was initiated to establish a large-scale repository of biological samples and detailed clinical information about children diagnosed with ASD
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HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasisTo understand how HLA-DR contributes to disease pathogenesis, we examined expression at the protein level in circulating myeloid and lymphoid cells of VL patients