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Fc-Engineered B7-H3 Antibody with Prolonged Serum Half-Life for Enhanced Cancer TherapyMonoclonal antibodies are revolutionizing the landscape of current cancer treatment, bringing hope to patients with incurable cancers. B7-H3 (CD276) is an attractive therapeutic target for antibody-based therapy due to its low or absent expression in normal tissues and high expression in various types of tumors, including prostate cancer, pancreatic cancer, and high-mortality esophageal squamous cell carcinoma (ESCC). In recent years, various B7-H3-targeting antibodies have been developed for cancer treatment, with a few making their way to clinical trials.
Research
A Scoping Review of Methodologies Exploring Diet and Health Outcomes in Lactating Women: What Has Been Done and Where to Next?Developing dietary guidelines for lactating women presents significant challenges, due to limited evidence being available on their specific nutrient needs and the biological impacts of various dietary dimensions. Current dietary recommendations often rely on data from nonlactating women, leading to potential inaccuracies.
Within the Institute, we have a commitment to the highest standards of research with pro-active staff ensuring the lab environment is safe and secure.
Young people and their families have teamed up with youth mental health providers and researchers to deliver a report which tackles youth suicide in WA.
A global network of researchers and clinicians, co-led by The Kids’ Professor Graham Hall, has transformed international best practice in identifying low lung function and diagnosing and treating lung disease.
Cutting-edge work is offering new hope to children with Cystic Fibrosis.
It's normal for children and teenagers to experience a range of emotions, including sadness, however childhood depression is more than just feeling sad.
Research
MelanomaMelanoma, also known as malignant melanoma, occurs when abnormal skin cells multiply rapidly in an uncontrolled way.
Research
Brain TumourBrain tumours are the second most common cancer in children (after leukaemia).
More than 3,000 skin checks have been undertaken as part of a large clinical trial in WA’s Kimberley region aimed at halving the burden of skin sores in school-aged Aboriginal children.