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Research

Immunological processes driving IgE sensitisation and disease development in males and females

In this review, we discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system

Research

Topical antibiotics with steroids for chronic suppurative otitis media

To assess the effects of adding a topical steroid to topical antibiotics in the treatment of people with chronic suppurative otitis media

Research

Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches

Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation

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Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children With and Without an Acute Wheezing Exacerbation

Time to reinfection with subsequent rhinovirus is not influenced by the species of the preceding rhinovirus

Research

Vagus nerve stimulation for the treatment of refractory epilepsy in the CDKL5 Deficiency Disorder

Our study suggests that vagus nerve stimulation is a generally safe and effective adjunct treatment for CDKL5-associated epilepsy

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What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analyses

There remains uncertainty about the effect of exercise on oxidative stress in people with Down syndrome

Research

Hypermasculinised facial morphology in boys and girls with Autism Spectrum Disorder and its association with symptomatology

This is the first study demonstrating facial hypermasculinisation in ASD and its relationship to social-communication difficulties in prepubescent children

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Parents’ interest in their child's education and children's outcomes in adolescence and adulthood: Does gender matter?

We found no evidence of gender-specific effects for the outcomes of academic achievement, educational expectations or educational attainment in adulthood.

Research

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis

CFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease