Phil Stumbles
Research Fellow and Program Head, Immunity and Inflammation
BSc (Hons.) PhD
phil.stumbles@telethonkids.org.au
Phil is a Research Fellow in the Experimental Immunology Research Team and Program Head of the Immunity and Inflammation program and The Kids Research Institute Australia. He is also an Associate Professor in Pathology at Murdoch University, where he holds a tenured academic teaching position. He completed his PhD in immunology in 1994 at Murdoch University and has held postdoctoral positions at the University of Oxford, University of Western Australia and The Kids Research Institute Australia.
His research is focused on understanding the regulation of immune defence mechanisms in the lungs, including the role of respiratory dendritic cells in regulating immunological tolerance, the pathogenesis of allergic inflammatory disorders such as allergic asthma, and in protection against, and recovery from, respiratory viral infections including influenza A virus. As part of the Early Environment Research Focus Area at The Kids Research Institute Australia, and in collaboration with A/Prof Deb Strickland, he also has interests in developing new approaches strategies for enhancing and restoring immune tolerance in early life as an approach to boosting respiratory defence mechanisms to provide enhanced anti-viral defence and prevent damaging inflammatory responses.
Projects
ORIGINS of Neurodevelopmental Risk and Resilience
This project aims to better understand the early genetic and environmental factors that the developing brain during a child’s first five years of life.
Published research
Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection
The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood.
Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection
Influenza A virus is the only influenza virus causing flu pandemics. Influenza is a highly contagious disease that can be deadly, especially in high-risk groups. Worldwide, these annual epidemics are estimated to result in about 3 to 5 million cases of severe illness and in about 290,000 to 650,000 respiratory deaths.
Inflammation induces α1-adrenoceptor expression in peripheral blood mononuclear cells of patients with complex regional pain syndrome
Persistent regional and systemic inflammation may promote pain and hyperalgesia in complex regional pain syndrome. In this study, we investigated whether stimulation of α1-adrenoceptors on peripheral blood mononuclear cells might contribute to this inflammatory state.
In Vivo Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection
Respiratory syncytial virus (RSV) causes annual epidemics of infections affecting the whole population. In vitro, it has been shown to infect and persist in human dendritic cells (DCs) for prolonged periods. Initially persistence is associated with low levels of replication before the virus becomes dormant. Reactivation of viral replication can be triggered many months later.
Stimulation of alpha-1 adrenoceptors may intensify cutaneous inflammation in complex regional pain syndrome
Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup of patients with complex regional pain syndrome. Activating α 1 -adrenoceptors in epidermal cells increases production of the proinflammatory cytokine interleukin-6, a mediator of inflammation.
Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85
Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways.
Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85
Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways.
Education and Qualifications
- PhD (Murdoch University, 1994)
- BSc (Hons.) (Murdoch University, 1990)
Awards/Honours
- 2017 – Western Australian Health Department Merit Award (Australia)
- 2016 – Asthma Foundation of Western Australia Distinguished Service Award (Australia)
- 2015 – University of Bern Visiting Professorship Award (Switzerland)
Active Collaborations
- Prof Christophe von Garnier, Pulmonology Dept, University of Lausanne, Switzerland
- Dr Fabian Blank, Department of Clinical Research, University of Bern, Switzerland
- A/Prof Deborah Strickland, The Kids Research Institute Australia, Perth, Australia