Researchers

Humanized CD70-targeted CAR-T cells with reduced fratricide demonstrate potent antitumor activity against AML and RCC

Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in B-cell malignancies, but its application in acute myeloid leukemia (AML) and renal cell carcinoma (RCC) remains challenging due to the lack of ideal target antigens. CD70 is highly expressed on AML and RCC tumor cells, while its expression in normal tissues is largely restricted to activated lymphocytes, making it a promising immunotherapeutic target.

Associations between maternal nutrition among women with hyperglycaemia in pregnancy and childhood anthropometry: The PANDORA cohort

The aim of this study was to describe the associations of nutrition during pregnancy with childhood anthropometry among First Nations and non-First Nations women with hyperglycaemia in pregnancy.

Maternal RSVpreF Vaccine Effectiveness Against Respiratory Syncytial Virus in Hospitalized Infants

In February 2025, Australia introduced maternal vaccination with bivalent respiratory syncytial virus prefusion F protein-based vaccine (RSVpreF) in the National Immunization Program for pregnant individuals from 28 weeks' gestation as the primary, year-round strategy to prevent RSV disease in infants 6 months of age or younger.

Are Sensory Features a Subdomain of Restricted and Repetitive Behaviors? Evaluating Empirical Support for the DSM-5 Autism Criteria

Following calls to formally recognize sensory differences in the autism diagnostic criteria, the DSM-5 introduced sensory features as a subdomain of restricted and repetitive behaviors. However, this categorization was developed based on expert consensus, rather than being empirically derived.