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P4 Respiratory Health for Kids

The P4 Respiratory Health for Kids Team is a multi-disciplinary group with skills in clinical medicine, physiology, psychology, and in cellular and molecular biology, that are committed to improving the lives of children with respiratory diseases and their families.

Through local, national and international collaborations, the team will accelerate innovation in child respiratory health and translation of these discoveries into clinical practice and policy.

A major area of focus for the team is Cystic Fibrosis (CF), the most common chronic, life-shortening genetic condition affecting Australians. Our team leads the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF), a collaborative group of over 30 doctors, allied health professionals and researchers dedicated to improving the respiratory health of children with CF by translating scientific research into tangible clinical outcomes. Research by our group and others has shown that infants and children with CF exhibit reduced lung function and evidence of inflammation and infection at a very early age. This highlights the need for new treatments that can be given from time of diagnosis to prevent and/or reverse the damage.

Learn more about the AREST team here.

Team members (22)

Helga Mikkelsen
Helga Mikkelsen

BSc MSc PhD Cantab

Project Manager, Respiratory Health

AI and Data Analytics Lead, Respiratory Research

Postdoctoral Research Officer

Laura Akesson

Laura Akesson

Honorary Research Associate

Georgia Banton

Georgia Banton

Clinical Trial Coordinator

Josh Beeson

Josh Beeson

Project Officer

Oded Breuer

Oded Breuer

Honorary Research Fellow

Daan Caudri

Daan Caudri

Honorary Research Fellow

Barry Clements

Barry Clements

Honorary Research Fellow

Eleanor Ferguson

Eleanor Ferguson

Clinical Trials Coordinator

Alexia Foti

Alexia Foti

Project Manager, Synergy

Sam Eastcott

Sam Eastcott

Clinical Trial Manager

Alya Ishak

Alya Ishak

Collaborator

Yuliya Karpievitch

Yuliya Karpievitch

AI and Data Analyst, Biostatistician

Rebecca Langford

Rebecca Langford

Program Manager, Cystic Fibrosis Research

Kak-Ming Ling

Kak-Ming Ling

Research Assistant

Jaqueline Macpherson

Jaqueline Macpherson

Research Coordinator

Fergal O'Gara

Fergal O'Gara

Honorary Distinguished Research Associate

Liz Starcevich

Liz Starcevich

Research Study Coordinator

José Caparrós Martín

José Caparrós Martín

Research Fellow

Clare Berry

Clare Berry

Program Manager, Wal-yan Respiratory Research Centre

David Hancock

David Hancock

Honorary Research Fellow Team Member

P4 Respiratory Health for Kids projects

Featured projects

SYNERGY CF: Getting the best start to life - preventing early cystic fibrosis lung disease by solving the host-inflammation infection conundrum

Cystic fibrosis related progressive lung disease characterised by inflammation and infection commences soon after birth.

SHIP CT: A Phase 3 randomised, double-blind, controlled trial of inhaled 7% hypertonic saline versus 0.9% isotonic saline for 48 weeks in patients with Cystic Fibrosis at 3-6 years of age in parallel with the North American SHIP clinical trial.

SHIP-CT, led by Professor Stephen Stick, Director of the Wal-yan Respiratory Research Centre at The Kids, is a unique study in preschool-aged children (from 3-6 years of age) with CF using images of the lung from chest CT scans as the main outcome measure.

Reports and Findings

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Bile acids in the lower airways is associated with airway microbiota changes in chronic obstructive pulmonary disease: an observational study

Chronic obstructive pulmonary disease (COPD) is a complex disorder with a high degree of interindividual variability. Gastrointestinal dysfunction is common in patients with COPD and has been proposed to influence the clinical progression of the disease. Using the presence of bile acid(s) (BA) in bronchoalveolar lavage (BAL) fluid as a marker of gastric aspiration, we evaluated the relationships between BAs, clinical outcomes and bacterial lung colonisation.

Virome assembly reveals draft genomes of native Pseudomonas phages isolated from a paediatric bronchoalveolar lavage sample

We present lung virome data recovered through shotgun metagenomics in bronchoalveolar lavage fluid from an infant with cystic fibrosis, who tested positive for Stenotrophomonas maltophilia infection. Using a bioinformatic pipeline for virus characterization in shotgun metagenomic data, we identified five viral contigs representing Pseudomonas phages classified as Caudoviricetes.

Does lung function in preschoolers help to predict asthma in later life?

The earliest respiratory function assessments, within or close to the neonatal period, consistently show correlations with lung function and with the development of asthma into adulthood. Measurements of lung function in infancy reflect the in utero period of lung development, and if early enough, show little influence of postnatal environmental exposures. 

Phage therapy to treat cystic fibrosis Burkholderia cepacia complex lung infections: perspectives and challengesge

Burkholderia cepacia complex is a cause of serious lung infections in people with cystic fibrosis, exhibiting extremely high levels of antimicrobial resistance. These infections are difficult to treat and are associated with high morbidity and mortality. 

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