Desiree Silva
Co-Head, ORIGINS
MBBS, FRACP, MPH, PhD
Professor Desiree Silva is Co-Director of ORIGINS and a Professor of Paediatrics at the University of Western Australia and Joondalup Health Campus. Desiree qualified as a doctor in the UK and completed her paediatric specialist training in Western Australia and the Northern Territory. She has a strong interest in neurodevelopmental disorders with over 20 years experience in managing children diagnosed with ADHD, autism, anxiety and developmental disorders. She has had extensive leadership experience in her role as professor of paediatrics for over 6 years, head of paediatrics and neonataology at Joondalup Health Campus for over 12 years and research experience for over 20 years. In 1998 she worked with Western Australian Health Department on a Needs Analysis which has enabled her to be part of translational research with the Paediatric Implementation Plan which provides state-wide service level recommendations, strategies and actions for Western Australia. Desiree was the lead paediatrician in the swimming pool project, which looked at the health benefits of swimming pools in remote Aboriginal communities. Her PhD on risk factors and outcomes for ADHD enabled her to recognise the limited up to date information available for parents and teachers and published the ADHD GO-TO GUIDE for teachers and parents through UWA Publishing that is currently one of their top selling books. She also has a special interest in understanding early brain development, nature relatedness and improving the lives of children and parents who have mental health conditions.
More recently she is the founding project Co-Director for ORIGINS. She was instrumental in developing relationships between the Paul Ramsay Foundation and Federal Government via Telethon to enable core funding of $26 million over 10 years for ORIGINS.
Desiree has published widely in international journals, which include Pediatrics and Lancet Psychiatry. She has been asked to speak at the world ADHD congress (2013, 2015, 2017). She was also an invited speaker at the International Paediatric Congress (2016) and at the International Data Linkage conference on the use of data linkage systems to understand ADHD. She was an invited speaker at the National Psychiatry Congress, Japan and the recipient of the rising Star award at Science on the Swan (2018). Desiree is currently a board member at St Mary’s Anglican Girls School since 2009 and Nature Play WA since 2015. She is on a number of hospital and community working groups which include the JHC Reconciliation Action Plan. She is a strong advocate for a good work life balance enjoying nature and adventure sports.
Projects
Global Scales for Early Development: Piloting the Family Check Up Program
Every year, over 80,000 Western Australian children will have a diagnosed mental health disorder.
COCOON: Virus transmission, immunity, and family wellbeing during COVID-19
ORIGINS community wellbeing during the COVID-19 pandemic
Kindy Readiness Project
October 2021
Mums Minds Matter
December 2020
Developmental Pathways in WA Children Project (Developmental Pathways Project)
Water Quality and the Microbiome Study (TUMS): The effects of chlorinated drinking water on the assembly of the infant gut microbiome
The Engage Study: discovering and delighting in your baby - a pilot study
Screen ORIGINS
August 2020
Early Moves
The Early Moves study is investigating whether a baby’s early movements can predict difficulties with learning (known as cognitive impairment) later in childhood.
August 2020
ADAPTS: Antibiotic Dysbiosis And Probiotics Trial in infantS
Newborn Nasal Sampling Evaluation (NOSE) Study
A Family's Journey at JHC: Analyses of routinely collected data
The impact of a Mediterranean diet and physical activity in pregnancy on gestational weight gain and neonatal body composition at birth and 1 year of age
The SYMBA Study - Promoting Gut Health (SYMBiosis) for Allergy prevention
Published research
Influence of maternal and infant technology use and other family factors on infant development
Data resource profile: the ORIGINS project databank: a collaborative data resource for investigating the developmental origins of health and disease
The ORIGINS Project (“ORIGINS”) is a longitudinal, population-level birth cohort with data and biosample collections that aim to facilitate research to reduce non-communicable diseases and encourage ‘a healthy start to life’. ORIGINS has gathered millions of datapoints and over 400,000 biosamples over 15 timepoints, antenatally through to five years of age, from mothers, non-birthing partners and the child, across four health and wellness domains.
Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: A randomized controlled trial
Ingestion of prebiotics during pregnancy and lactation may have immunomodulatory benefits for the developing fetal and infant immune system and provide a potential dietary strategy to reduce the risk of allergic diseases. We sought to determine whether maternal supplementation with dietary prebiotics reduces the risk of allergic outcomes in infants with hereditary risk.
The ORIGINS Project: A Cross-Sectional Analysis of the Nutrition Profile of Pregnant Women in a Longitudinal Birth Cohort
Pregnancy is an opportunistic time for dietary intake to influence future disease susceptibility in offspring later in life. The ORIGINS Project was established to identify the factors that contribute to 'a healthy start to life' through a focus supporting childhood health and preventing disease (including non-communicable diseases).
Probiotic supplementation in neonates and long-term gut colonisation: A systematic review of randomised controlled trials
Probiotic supplementation in the neonatal period results in improved gut colonisation with probiotic bacteria in the short term. There is limited information on the long-term sustainability of this colonisation.
Perinatal Women’s Perspectives of, and Engagement in, Digital Emotional Well-Being Training: Mixed Methods Study
Psychological distress in the early postpartum period can have long-lasting deleterious effects on a mother's well-being and negatively affect her infant's development. Intervention approaches based in contemplative practices such as mindfulness and loving-kindness and compassion are intended to alleviate distress and cultivate well-being and can be delivered effectively as digital mental health interventions.
Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant
Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from <21 weeks' gestation to six months' post-partum, in a double-blinded, randomised placebo-controlled trial.
Metagenomic Characterisation of the Gut Microbiome and Effect of Complementary Feeding on Bifidobacterium spp. in Australian Infants
Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine whether the age at which solid foods are introduced differentially affects the microbiota in predominantly breastfed infants compared with predominantly formula-fed infants.
Study Protocol for a Stepped-Wedge Cluster (Nested) Randomized Controlled Trial of Antenatal Colostrum Expression (ACE) Instruction in First-Time Mothers: The ACE Study
Although many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers.
Altered dietary behaviour during pregnancy impacts systemic metabolic phenotypes
Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers.
Experience of primary caregivers in utilising an mHealth application for remote dental screening in preschool children
This study aimed to address the acceptance of mHealth applications for a dental screening app that facilitates patient information entry and captures dental photos remotely to assist in caries diagnosis in preschool children in Australia.
The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and Disease
Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORIGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections.
Time-out for well-being: A mixed methods evaluation of attitudes and likelihood to engage in different types of online emotional well-being programmes in the perinatal period
Positive maternal mental health during the perinatal period contributes to general well-being and positive emotional bonds with the child, encouraging an optimal developmental trajectory. Online interventions to enhance maternal well-being and develop coping skills, such as meditation-based interventions, can be a low-cost way to improve mother and child outcomes.
Feasibility and safety of introducing cashew nut spread in infant diets-A randomized trial
To reduce peanut allergy prevalence, infant feeding guidelines now recommend introducing peanuts in an age-appropriate form (such as peanut butter) as part of complementary feeding. However, due to a lack of randomized trial evidence, most infant feeding and food allergy prevention guidelines do not include tree nuts. The aims of this trial were to determine safety and feasibility of dosage consumption recommendations for infant cashew nut spread introduction.
“It helps and it doesn’t help”: maternal perspectives on how the use of smartphones and tablet computers influences parent-infant attachment
As families increase their use of mobile touch screen devices (smartphones and tablet computers), there is potential for this use to influence parent-child interactions required to form a secure attachment during infancy, and thus future child developmental outcomes. Thirty families of infants (aged 9-15 months) were interviewed to explore how parents and infants use these devices, and how device use influenced parents' thoughts, feelings and behaviours towards their infant and other family interactions.
The feasibility of a digital health approach to facilitate remote dental screening among preschool children during COVID-19 and social restrictions
Tele-dentistry can be useful to facilitate screening of children, especially those living in rural and remote communities, and during the COVID-19 pandemic. This study evaluated the feasibility of tele-dental screening for the identification of early childhood caries (ECC) in preschoolers using an app operated by their parents with remote review by oral-health therapists.
Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review
The aim of this review was to map the literature assessing associations between maternal or infant immune or gut microbiome biomarkers and child neurodevelopmental outcomes within the first 5 years of life. We conducted a PRISMA-ScR compliant review of peer-reviewed, English-language journal articles.
Longitudinal changes in wellbeing amongst breastfeeding women in Australia and New Zealand during the COVID-19 pandemic
The COVID-19 pandemic has impacted new mothers’ wellbeing and breastfeeding experience. Women have experienced changes in birth and postnatal care and restricted access to their support network. It is unclear how these impacts may have changed over time with shifting rates of infection and policies restricting movement and access to services in Australia and New Zealand.
Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months’ Post-Partum on Child Allergic Disease Outcomes
Infant allergy is the most common early manifestation of an increasing propensity for inflammation and immune dysregulation in modern environments. Refined low-fibre diets are a major risk for inflammatory diseases through adverse effects on the composition and function of gut microbiota. This has focused attention on the potential of prebiotic dietary fibres to favourably change gut microbiota, for local and systemic anti-inflammatory effects.
Health-related behaviours and weight status of expectant fathers
Little attention has been given to the health status and lifestyle behaviours of expectant fathers. This study aimed to examine health-related variables in a cohort of expectant fathers to identify potential focus areas for interventions designed to optimise health and wellbeing outcomes in this group.
Anti-Müllerian hormone concentration is associated with central adiposity and reproductive hormones in expectant fathers
The role of the anti-Müllerian hormone (AMH) as an indicator of physical and reproductive health in men is unclear. We assessed the relationships between AMH and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and metabolic parameters, in a cohort of expectant fathers.
‘There’s good and bad’: parent perspectives on the influence of mobile touch screen device use on prenatal attachment
The potential for human-computer interaction to have a substantial impact on adults is well documented. However, its potential importance prior to birth has rarely been reported. Parental use of smartphones and tablet computers could influence the relationship between parent and baby during pregnancy (prenatal attachment) and thus child development.
The impact a Mediterranean Diet in the third trimester of pregnancy has on neonatal body fat percentage
Maternal diet during pregnancy has long been recognised as an important determinant of neonatal outcomes and child development. Infant body composition is a potentially modifiable risk factor for predicting future health and metabolic disease.
“Coronavirus Changed the Rules on Everything”: Parent Perspectives on How the COVID‐19 Pandemic Influenced Family Routines, Relationships and Technology Use in Families with Infants
This study explores how the first wave of the COVID‐19 pandemic influenced family routines, relationships and technology use (smartphones and tablet computers) among families with infants. Infancy is known to be an important period for attachment security and future child development, and a time of being susceptible to changes within and outside of the family unit.
“Coronavirus Changed the Rules on Everything”: Parent Perspectives on How the COVID‐19 Pandemic Influenced Family Routines, Relationships and Technology Use in Families with Infants
This study explores how the first wave of the COVID‐19 pandemic influenced family routines, relationships and technology use (smartphones and tablet computers) among families with infants. Infancy is known to be an important period for attachment security and future child development, and a time of being susceptible to changes within and outside of the family unit.
Comparison of experiences in two birth cohorts comprising young families with children under four years during the initial Covid-19 lockdown in Australia and the UK: A qualitative study
This study aims to understand the experience and impact of the initial COVID-19 lock-down in young families with children aged below 4 years. Free text questions were administered to participants in the ORIGINS (Australia) and Born in Bradford (UK) cohort studies to collect qualitative information on worries, concerns and enjoyable experiences during the pandemic.
The association of mobile touch screen device use with parent-child attachment: a systematic review
Mobile touch screen devices (smartphones and tablet computers) have become an integral part of many parents’ and children’s lives, with this interaction linked to physical, mental and social outcomes. Despite the known importance of parent-child attachment, evidence on the association between device use and attachment was yet to be reviewed.
Developmental Origins of Health and Disease (DOHaD): The importance of life-course and transgenerational approaches
With well-established evidence that early life conditions have a profound influence on lifespan and health-span, new interventional birth cohorts are examining ways to optimise health potential of individuals and communities. These are aimed at going beyond preventing disease, to the conditions that facilitate flourishing from an early age.
Wellbeing of breastfeeding women in australia and new zealand during the covid‐19 pandemic: A cross‐sectional study
During the COVID-19 pandemic, breastfeeding women have experienced restricted access to support, placing them at increased risk of mental health concerns and limited breastfeeding assistance. This study investigated the effect of the pandemic on feeding choices and maternal wellbeing amongst breastfeeding mothers living in Australian and New Zealand. We conducted a cross-sectional online survey that examined feeding methods, maternal mental wellbeing, worries, challenges, and positive experiences during the pandemic.
Comparing Web-Based Mindfulness With Loving-Kindness and Compassion Training for Promoting Well-Being in Pregnancy: Protocol for a Three-Arm Pilot Randomized Controlled Trial
Promoting psychological well-being and preventing distress among pregnant women is an important public health goal. In addition to adversely impacting the mother's health and well-being, psychological distress in pregnancy increases the risk of poor pregnancy outcomes, compromises infant socioemotional development and bonding, and heightens maternal and child vulnerability in the postpartum period. Mindfulness and compassion-based interventions show potential for prevention and early intervention for perinatal distress.
Introducing the ORIGINS project: a community-based interventional birth cohort
Non-communicable diseases (NCDs) pose the greatest threat to human health globally. The dramatic rise in early onset NCDs - such as childhood obesity, the allergy epidemic and an increasing burden of mental ill health in children and youth - reflect the profound early impact of modern environments on developing systems.
Literacy and Numeracy Underachievement in Boys and Girls With ADHD
Children with ADHD are disadvantaged from an early age in key areas of learning, and this risk increased with reduction in gestational age at birth
Feasibility of conducting an early pregnancy diet and lifestyle e-health intervention: The Pregnancy Lifestyle Activity Nutrition (PLAN) project
A lifestyle intervention starting in the first-trimester pregnancy utilising e-health mode of delivery is feasible
The ORIGINS Project
ORIGINS is a new birth cohort study, collecting detailed information about the early environment's influence on a broad range of non-communicable diseases
December 2018